This page keeps track of new/upcoming treatment options for epilepsy and seizure disorders. What’s in development? What’s promising? What’s available soon? Find out below… Current topics include pY816, PI3K inhibitors, LY294002, FK506, nucleic acid aptamers, TrkB inhibitors, TAK-935, triheptanoin (C7), cenobamate (YKP3089), STK-001, stem cells, VAL-0417, gene therapy, osthole, Voronistat, and more.
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News
- Discovery Of Gabaergic Synaptic Regulations Inside The Brain For A New Epilepsy Treatment Mar 3, 2020
- CBD Oil for Treating Epilepsy: FDA approval of cannabidiol to reduce seizures is limited to severe, rare types of epilepsy Feb 26, 2020
- EU funds €3 million project to develop nanodevices against epilepsy and other neurological diseases Feb 4, 2020
- EPILEPSY’S NEXT FRONTIER: As epilepsy drugs fail nearly one-third of patients, scientists seek root causes of seizures Dec 12, 2019
- Neurocrine and Xenon join forces on epilepsy treatment Dec 2, 2019
- Digital Health Trial Uses AI For Better Epilepsy Treatment Decisions Dec 2, 2019
- Investigational Drug for People with Treatment-Resistant Epilepsy Nov 21, 2019
- Transplanting new inhibitory neurons may repair damaged brain circuits, improve memory, and stop seizures Nov 15, 2019
- Old Treatment For Parkinson’s Disease Now Being Used For Epilepsy Nov 12, 2019
- Researchers develop new therapeutic concept for treatment of temporal lobe epilepsy Oct 30, 2019
- New gene therapy for epilepsy provides on-demand release of endogenous substance: Preclinical study shows long-term suppression of seizures Oct 30, 2019
- Zogenix Announces Positive New Data for Its Investigational Drug, FINTEPLA® (ZX008, fenfluramine), for the Treatment of Seizures Associated with Dravet Syndrome Oct 25, 2019
- Study Published in Neurology Shows Chronic Epilepsy Associated with Marker of Cardiac Electrical Instability Oct 23, 2019
- Cadence Neuroscience raises $15M for epilepsy treatment created at Mayo Clinic Oct 11, 2019
- New ‘rogue waves’ test pinpoints epilepsy seizure brain zones Oct 2, 2019
- Cannabidiol gel reduces seizures in children with severe epilepsy, Australasian trial shows Oct 1, 2019
- Brain’s ‘Push-Pull’ Can Control Drug-Resistant Seizures Sep 30, 2019
- GW Pharma to launch first CBD-based epilepsy drug in Europe ‘over the next year or two,’ CEO says Sep 24, 2019
- Treating epilepsy with physics Sep 10, 2019
- UH associate professor awarded NIH grant to test new treatment for epilepsy patients Sep 10, 2019
- Testing new treatment for epilepsy patients Sep 9, 2019
- Stoke Therapeutics Granted FDA Orphan Drug Designation for STK-001, an Investigational New Treatment for Dravet Syndrome Aug 6, 2019
Research
- Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects Feb 7, 2020
- Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy Feb 5, 2020
- Probiotic and Nigella sativa extract supplementation protected against seizure, seizure-induced cognitive impairment, and hippocampal long-term potentiation in kindled rats Feb 4, 2020
- Deficiency of SCAMP5 Leads to Pediatric Epilepsy and Dysregulation of Neurotransmitter Release in the Brain Feb 4, 2020
- Gene Therapy Repairs for Epileptic Brain: Potential for Treatment and Future Directions Jan 31, 2020
- The Potential Anti-Epileptic Effect of Protein-Rich Extract From Bombyx Batryticatus Jan 28, 2020
- STAT3 polymorphism was associated with the risk of epilepsy and drug resistance to epilepsy Jan 27, 2020
- Role of NKCC1 and KCC2 in Epilepsy: potential therapeutic targets for the development of novel antiepileptic drugs Jan 17, 2020
- P2Y1-targeting therapies as novel treatment for drug-refractory status epilepticus Jan 16, 2020
- Nucleic Acid Aptamers for Molecular Therapy of Epilepsy and Blood-Brain Barrier Damages Nov 14, 2019
- Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial Nov 13, 2019
- Neuroinflammation impact in epileptogenesis and new treatment strategy Oct 25, 2019
- Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation Oct 22, 2019
- Promise of extracellular vesicles (EVs) for diagnosis and treatment of epilepsy Oct 18, 2019
- Ketogenic Diet and Epilepsy: review of the latest data from randomized clinical trials, practice guidelines, and new research areas over the past 2 years Oct 18, 2019
- Early polytherapy for benzodiazepine-refractory status epilepticus Oct 18, 2019
- Can we ‘seize’ the gut microbiota to treat epilepsy? Oct 15, 2019
- Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A potential novel drug for epilepsy Oct 13, 2019
- Pharmacogenetics and the treatment of epilepsy: what do we know? Oct 7, 2019
- Recent Advances in the Drug Treatment of Dravet Syndrome Sep 23, 2019
- Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy Sep 18, 2019
- Stem cells: a path towards improved epilepsy therapies Sep 17, 2019
- Prospective evaluation of oral cannabis extracts in children with epilepsy Sep 16, 2019
- Relevance of Surface Neuronal Protein Autoantibodies as Biomarkers in Seizure-Associated Disorders Sep 13, 2019
- FK506 Attenuated Epilepsy by Reducing Inflammation in Rats Sep 12, 2019
- Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats Sep 11, 2019
- Mechanisms and Uses of Dietary Therapy as a Treatment for Epilepsy: A Review Sep 11, 2019
- Brivaracetam in the treatment of epilepsy: a review of clinical trial data Sep 9, 2019
- Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: promising candidates for developing into anti-epileptic drugs Sep 6, 2019
- No prevention or cure of epilepsy as yet Sep 6, 2019
- Novel Optogenetic Approaches in Epilepsy Research: toward developing new treatment options Sep 6, 2019
- Dynorphin-based “release on demand” gene therapy for drug-resistant temporal lobe epilepsy Sep 5, 2019
- dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice Sep 3, 2019
- G protein-coupled receptors (GPCR) downstream effectors may provide antiepileptic and/or antiepileptogenic targets Aug 24, 2019
- Alterations in GABAA Receptor Subunit Expression in the Amygdala and Entorhinal Cortex in Human Temporal Lobe Epilepsy: insights that could lead to the development of novel therapeutic agents Aug 22, 2019
- Biomarkers For Epileptogenesis And Its Treatment Aug 1, 2019
- VAL-0417 is a promising drug for the treatment of Lafora Disease (LD) and a putative precision therapy platform for intractable epilepsy Jul 25, 2019
- The path from scientific discovery to cures for epilepsy Jul 10, 2019
- Osthole may be useful in the treatment of epilepsy and other neurodegenerative diseases characterized by over expression of PI3K/Akt/mTOR Mar 28, 2019
- Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits: DGCs as a potential therapeutic target for treating epilepsy Dec 3, 2018
Clinical Trials
- Pilot Trial to Evaluate The Effect of Oral Methylprednisolone on Seizure Frequency in Children With Epilepsy Feb 7, 2020
- A Phase 2, Prospective, Interventional, Open-Label, Multi-Site, Extension Study to Assess the Long-Term Safety and Tolerability of TAK-935 (OV935) as Adjunctive Therapy in Patients With Rare Epilepsy (Endymion) Dec 5, 2019
- Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic Clonic Seizures Nov 22, 2019
- A Study With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Perampanel (E2007) Administered as an Adjunctive Therapy in Subjects With Refractory Partial-onset Seizures Nov 5, 2019
- Cannabidiol in Children With Refractory Epileptic Encephalopathy: A Phase 1 Open Label Dose Escalation Study (CARE-E) Oct 17, 2019
- Pharmacokinetic Study With an Oral Suspension of Perampanel as Adjunctive Therapy in Pediatric Subjects With Epilepsy Oct 16, 2019
- A Long-term Safety and Tolerability Study of USL261 in Patients With Seizure Clusters [Terminated] Oct 10, 2019
- Study to Evaluate the Long-Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization Oct 8, 2019
- A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy Oct 7, 2019
- Safety and Tolerability Study of Diazepam Buccal Soluble Film (DBSF) in Subjects With Epilepsy Oct 3, 2019
- Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures Sep 26, 2019
- Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus Sep 25, 2019
- Study of Safety and Pharmacokinetics of Oral Doses of EPX-100 in Healthy Subjects Sep 20, 2019
- Treatment Development of Triheptanoin (C7) for Glucose Transporter Type I Deficiency (G1D) Aug 9, 2019
- Voronistat in Pediatric Patients With Drug Resistant Epilepsy Mar 29, 2019
- Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies [Completed] Nov 2, 2018